TABLE 4.

Virtual Twins results on the detection of predictive factors describing patients with a higher risk than the others in experiencing hypoglycemia under Premixed insulin than under Basal insulin (with or without Prandial insulin).

Subgroup Ranking a	Subgroup description	Treatment event rate Discovery/Test	Control event rate Discovery/Test	Treatment sample size Discovery/Test	Control sample size Discovery/Test	Risk Ratio Discovery/Test
S1	# of OGLD $\ge 2$ AND # of different lipid-lowering agents for dyslipidemia $\ge 1$	33%/34%	16%/26%	72/408	340/755	2.06/1.36
S2	# of OGLD $\le 2$ AND Duration of insulin therapy (year) $\ge 3$ AND # of different lipid-lowering agents for dyslipidemia $\ge$ 1	38%/39%	29%/32%	238/339	432/433	1.31/1.21
S3	Receives oral glycaemic lowering drugs = Yes AND Total serum triglycerides (mg/dL) $\ge 169.7$ AND # of different lipid-lowering agents for dyslipidemia $=0$	24%/33%	23%/27%	57/9	110/18	1.08/1.20

^aSubgroup ranking is based on risk ratios in discovery dataset

In the discovery dataset, risk ratios were computed after missing values imputation. In the test dataset, risk ratios were computed on the original dataset.