Skip to main content
. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Cancer Res. 2020 Jul 8;80(18):4004–4013. doi: 10.1158/0008-5472.CAN-20-0447

Table 2.

Association of genetic susceptibility to inflammatory intestinal disease groups and risk of PDAC in participants of European ancestry from PanScan and PanC4 studiesa

Index-SNP defined region
 Excluding previous PDAC GWAS locic
Disease group n SNPb, n P-value n SNP, n P-value
Ulcerative colitis 99 728 0.0040 96 716 0.0029
Crohn’s disease 151 997 0.0057 151 997 0.0057
Inflammatory bowel disease 211 1,403 0.011 208 1,393 0.0098
Celiac disease 21 148 0.22 21 148 0.22
Chronic pancreatitis 11 35 3.4 × 10−6 10 32 0.073
Primary sclerosing cholangitis 15 109 0.078 15 109 0.078

Abbreviations: GWAS, genome-wide association study; PDAC, pancreatic ductal adenocarcinoma; SNP, single-nucleotide polymorphism.

a

The analysis (N=8,384 cases and 11,955 controls) was adjusted for age, sex, study, geographic region, and the top eigenvectors for the PanScan studies and age, sex, and the top eigenvectors for the PanC4 studies.

b

These SNPs are within +/− 500kb genomic regions around index-SNPs and correlated with index-SNPs at r2 > 0.80.

c

Results were obtained after excluding +/− 500kb genomic regions of 20 PDAC GWAS risk signals.