TABLE 1.

Diagnostic criteria for engraftment syndrome

Major criteria	Temperature ≥ 38.3 °C with no identifiable infectious etiology
	Erythrodermatous rash involving > 25% of body surface area and not attributable to a medication
	Noncardiogenic pulmonary edema, manifested by diffuse pulmonary infiltrates consistent with this diagnosis, and hypoxia
Minor criteria	Hepatic dysfunction with either bilirubin ≥ 2 mg/dL or transaminase levels ≥ 2 times normal
	Renal insufficiency (serum creatinine) ≥ 2 times baseline
	Weight gain ≥ 2.5% of baseline body weight
	Transient encephalopathy unexplainable by other causes

Diagnosis: all three major criteria or two major criteria and one or more minor criterion, within 96 hours of engraftment.