TABLE 3.

Maximum values of cytokines and procalcitonin (PCT) between day 0 (exclusive) and day 30 (inclusive), or day of engraftment, whichever came first. Medians and upper and lower quartiles are reported

	Engraftment syndrome			Culture positive infection			Acute GVHD
	Present	Absent	P	Present	Absent	P	Present	Absent	P
n	5	25		6	24		15	15
IFN-γ	18.4 (9.20, 31.5)	12.1 (3.50, 25.7)	0.70	25.7 (17.5, 40.1)	10.3 (3.05, 25.3)	0.12	5.80 (2.70, 24.6)	18.9 (8.90, 32.5)	0.10
IL-1b	0.90 (0.60, 1.10)	0.60 (0.30, 0.60)	0.11	0.60 (0.10, 0.90)	0.60 (0.55, 0.90)	0.65	0.60 (0.30, 1.10)	0.60 (0.50, 0.60)	0.23
IL-6	22.4 (7.70, 47.2)	10.9(6.20, 38.2)	0.45	24.7 (7.90, 47.2)	10.2 (5.90, 38.3)	0.35	9.5 (5.6, 93.0)	12.4 (6.70, 36.9)	0.87
IL-8	398.9 (70.6, 1463.1)	106.7 (37.8, 161.6)	0.21	158.9(126.5, 398.9)	83.9 (38.1, 189.6)	0.25	84.0 (57.5, 292.9)	126.5 (37.8, 215.4)	0.80
IL-10	48.5 (18.0, 48.6)	13.0 (5.60, 26.6)	0.25	91.3 (27.2, 116.7)	12.1 (5.45,21.2)	0.015	13.9 (7.00, 61.7)	17.8 (5.30, 27.2)	0.66
IL-12p70	1.50 (1.10, 3.00)	1.20 (0.70, 2.40)	0.62	6.70 (1.00, 41.6)	1.20 (0.70, 2.35)	0.23	1.50 (0.70, 2.40)	1.20 (0.80, 3.00)	0.97
TNF-α	10.6 (4.80, 18.4)	8.70 (5.10, 13.2)	0.66	9.30 (7.00, 17.5)	7.50 (5.10, 13.5)	0.53	8.70 (5.10, 17.5)	8.90 (5.10, 13.2)	0.62
PCTa	2.05 (0.95, 6.80)	0.54 (0.20, 0.95)	0.068	1.03 (0.38, 5.10)	0.54 (0.21, 1.05)	0.60	0.79 (0.31, 5.10)	0.50 (0.17, 1.50)	1.0

GVHD, graft-versus-host disease; IFN, interferon; IL, interleukin; TNF, tumor necrosis factor.

All values shown as the median (lower quartile, upper quartile).

^aProcalcitonin was dichotomized at 2.0 and was analyzed using Fisher’s exact test. All other cytokines were analyzed using the Wilcoxon rank sum test.