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. 2021 Jan 25;17(1):e1009246. doi: 10.1371/journal.ppat.1009246

Fig 3. Processing of the S protein multibasic site is essential for cell-cell fusion but furin is dispensable.

Fig 3

(A) and (D) Reconstructed images of the indicated cells lines transfected with the indicated S mutants and mixed with green-labelled cells at 24 hours post transfection. Scale bar 200 μm. Green colour identifies the acceptor cells while red colour marks donor cells. Merged green-red colours indicate the syncytia. (B) Quantification of green-red overlap area shown in (A) *P<0.05; **, P<0.01 analysed using Student t-test. (C) Time course of cell-cell fusion shown in (A). (E) Cell-cell fusion time course of images shown in (D). Data are expressed as mean +/- SEM (n = 2). Acceptor cells are marked in bold and italics.