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. 2021 Feb 4;16(2):e0246630. doi: 10.1371/journal.pone.0246630

Fig 5. Inhibition of IL-31-induced neurite outgrowth by PQA-18.

Fig 5

Neuro2A cells were treated with anti-IL-31Rα antibody in the absence or presence of PQA-18 at indicated concentrations, and the cell morphology was examined by microscopy. Neurites were defined as a process with lengths equivalent to one diameter of a cell body. The percentage of neurite-bearing cells was calculated from the total number of counted cells. The representative micrographs are shown (A), and the quantitative data of the neurite outgrowth are shown (B). Scale bar: 20 μm. Data are pooled from three independent experiments and shown as mean and SD. **p < 0.01 as compared with control; ##p < 0.01 as compared with anti-IL-31Rα antibody-treated group (one-way ANOVA/Tukey-Kramer post-hoc comparisons).