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Pkhd1fl/fl;Pkd1fl/+;Pax8rtTA;TetO-Cre has no kidney phenotype. (A) Representative kidney sections of the indicated genotype at 6 months of age. (B) Hematoxylin and eosin-stained kidneys from Pkhd1fl/fl; Pkd1fl/+;Pax8rtTA;TetO-Cre mice at 6 months of age. (C) Kidney weight/body weight ratio and (D) body weight of Pkhd1fl/fl;Pkd1fl/+;Pax8rtTA;TetO-Cre mice. Genotypes indicated by color corresponding to labels in (A). Blue shapes, males; pink shapes, female.
