Table 1. dN/dS is lower in spike than RdRp.

A single dN/dS value was computed for gene (or spike domain) and each human coronavirus (HCoV) using mixed effects model of evolution (MEME).

	RdRp	Spike	S1	S2
229E	0.143	0.441	0.662	0.166
OC43 lineage A	0.080	0.435	0.466	0.301
OC43 lineage B	0.061	0.317	0.418	0.234
NL63	0.068	0.139	0.121	0.038