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. 2021 Feb;21(1):5–18. doi: 10.17305/bjbms.2020.5036

FIGURE 1.

FIGURE 1

GSK3β activation, inactivation, and activity towards its key substrates. GSK3β – glycogen synthase kinase 3β; pGSK3β-Y216 – glycogen synthase kinase 3β phosphorylated at tyrosine 216; pGSK3β-S9 – glycogen synthase kinase 3β phosphorylated at serine 9; Y216 – tyrosine 216; S9 – serine 9; PKA – protein kinase A; Akt – protein kinase B; ILK – integrin-linked kinase; PP1 – protein-phosphatase 1; NICD1 – Notch 1 intracellular domain; Gli – glioma-associated oncogene; IκB – inhibitor κB; P – phosphate group; PYK2 – tyrosine protein kinase 2.