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. 2021 Feb 4;16(2):e0245285. doi: 10.1371/journal.pone.0245285

Table 3. Triggers and coping strategies for fatigue reported by cohort as a whole and in demographic subgroups.

n (% total cohort) n = 1029 Male, n (%) of total male n = 576 Female, n (%) of total female) n = 453 p-value (males vs females) * Age < 65, n (%) of total age < 65) n = 344 Age ≥ 65, n (%) of total age ≥ 65) n = 685 p-value (age <65 vs age ≥65)*
Patient-Reported Triggers
A poor night’s sleep 639 (62.1) 352 (61.1) 287 (63.4) 0.461 239 (69.5) 400 (58.4) 0.001
Physical exertion (e.g. strenuous exercise or participating in sports) 464 (45.1) 295 (51.2) 169 (37.3) <0.001 160 (46.5) 304 (44.4) 0.517
A busy day 455 (44.2) 221 (38.4) 234 (51.7) <0.001 186 (54.1) 269 (39.3) <0.001
Emotions, either negative or positive (stress, anger, joy, excitement, etc.) 314 (30.5) 159 (27.6) 155 (34.1) 0.022 132 (38.4) 182 (26.6) <0.001
Being overheated 228 (22.2) 119 (20.7) 109 (24.1) 0.192 91 (26.5) 137 (20.0) 0.019
Taking medication for PD 194 (18.9) 118 (20.5) 76 (16.8) 0.131 78 (22.7) 116 (16.9) 0.026
Fatigue is not triggered by specific experiences for me 128 (12.4) 71 (12.3) 57 (12.6) 0.902 30 (8.7) 98 (14.3) 0.010
Some other trigger(s) 78 (7.6) 35 (6.1) 43 (9.5) 0.040 27 (7.8) 51 (7.4) 0.818
Patient-Reported Coping Strategies
Sitting quietly (e.g. watching TV, listening to radio, reading, etc.) 598 (58.1) 316 (54.9) 282 (62.3) 0.017 185 (53.8) 413 (60.3) 0.046
Laying down to rest (not sleeping) 541 (52.6) 286 (49.7) 255 (56.3) 0.034 195 (56.7) 346 (50.5) 0.061
Sleeping 495 (48.1) 300 (52.1) 195 (43.0) 0.004 176 (51.2) 319 (46.6) 0.164
Exercising 195 (19.0) 113 (19.6) 82 (18.1) 0.538 76 (22.1) 119 (17.4) 0.068
Drinking coffee / caffeine 169 (16.4) 99 (17.2) 70 (15.5) 0.456 79 (23.0) 90 (13.1) <0.001
Taking medication 104 (10.1) 56 (9.7) 48 (10.6) 0.644 43 (12.5) 61 (8.9) 0.071
Eating 91 (8.8) 52 (9.0) 39 (8.6) 0.814 27 (7.8) 64 (9.3) 0.426
Meditating 80 (7.8) 35 (6.1) 45 (9.9) 0.022 28 (8.1) 52 (7.6) 0.757
Some other coping strategy 65 (6.3) 36 (6.3) 29 (6.4) 0.921 21 (6.1) 44 (6.4) 0.843
Sitting in a bath and/or jacuzzi 48 (4.7) 16 (2.8) 32 (7.1) 0.001 18 (5.2) 30 (4.4) 0.540

*bold values denote significant difference in proportion reporting specified trigger or alleviating factor based on post-hoc comparison of adjusted residuals if chi2-test omnibus p<0.05