Table 2.

SNPs associated with family history of colorectal cancer in the study population

Db SNP ID	Gene	Chr	SNP type	A/a	Controls genotype, n = 750			Cases genotype, n = 750			Genetic modela	Multivariate analysis
					AA	Aa	aa	AA	Aa	aa		ORb	95% CIb	P-value	Q-valuec
rs1136410	PARP1	1	V762A	A/G	567	163	17	575	162	5	Recessive	0.35	0.13–0.96	0.027	0.070
rs1800734	MLH1	3	Upstream	G/A	463	247	38	424	271	53	Log-additive	1.27	1.06–1.51	0.009	0.078
rs39453	OSBPL3/CYCS	7	Intergenic	T/C	357	313	80	310	351	88	Log-additive	1.20	1.02–1.41	0.028	0.117
rs12917	MGMT	10	L115F	C/T	536	204	10	524	202	23	Recessive	2.39	1.10–5.18	0.023	0.070
rs17094983	LINC01500	14	Intronic	G/A	508	213	27	558	174	15	Log-additive	0.72	0.58–0.89	0.002	0.037
rs16973225	LOC102724001	15	Intronic	A/C	640	107	1	665	76	7	Dominant	0.71	0.51–0.99	0.044	0.149
rs73376930	GREM1	15	Intronic	A/G	514	215	21	481	239	30	Log-additive	1.25	1.03–1.53	0.026	0.117
rs16940	BRCA1	17	L724L	A/G	302	370	76	340	319	89	Overdominant	0.75	0.61–0.94	0.011	0.088
rs4939827	SMAD7	18	Intronic	T/C	240	348	162	242	381	126	Recessive	0.73	0.55–0.96	0.023	0.070
rs13343954	RHPN2	19	Intronic	T/C	548	180	21	539	199	10	Recessive	0.42	0.18–1.01	0.040	0.070

The bold with italicized allele represents the colorectal cancer risk allele.

A/a, major/minor alleles; Chr, chromosome number; CI, confidence interval; n, number of individuals; OR, odds ratio; SNP, single nucleotide polymorphism.

^aThe best-fitting genetic model was selected using the Akaike information criteria.

^bORs and 95% CIs were calculated by logistic regression analysis adjusted by age, sex, tobacco, alcohol, drugs use (non-steroidal anti-inflammatory drugs and low-dose acetylsalicylic acid), and histological lesion.

^cQ values were obtained after applying the False Discovery Rate method for multiple comparisons. Q-values < 0.05 are highlighted in bold.