. 2021 Feb 3;12(2):e00301. doi: 10.14309/ctg.0000000000000301

Table 3.

SNPs associated with family history of colorectal cancer: stratified analysis by subtype of adenomas

Db SNP ID	Gene	Chr	SNP type	A/a	Controls genotype			Cases genotype			Genetic model^a	Multivariate analysis
Db SNP ID	Gene	Chr	SNP type	A/a	AA	Aa	aa	AA	Aa	aa	Genetic model^a	OR^b	95% CI^b	P-value	Q-value^c
Patients with low risk adenomas
rs1800734	MLH1	3	Upstream	G/A	93	42	9	77	55	11	Dominant	2.14	1.23–3.71	0.006	0.403
rs11255841	LINC00709	10	Intronic	T/A	91	42	11	72	68	3	Dominant	2.04	1.19–3.51	0.001	0.024
rs10795668	LINC00709	10	Intronic	G/A	86	44	14	67	71	6	Codominant	2.38	1.35–4.20	0.001	0.059

Db SNP ID	Gene	Chr	SNP type	A/a	Controls genotype			Cases genotype			Genetic model^a	Multivariate analysis
Db SNP ID	Gene	Chr	SNP type	A/a	AA	Aa	aa	AA	Aa	aa	Genetic model^a	OR^b	95% CI^b	P-value	Q-value^c
Patients with high risk adenomas
rs39453	OSBPL3/CYCS	7	Intergenic	T/C	84	78	15	58	98	20	Log-additive	1.63	1.12–2.36	0.010	0.698

A/a, major/minor alleles; Chr, chromosome number; CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism.

The best-fitting genetic model was selected using the Akaike information criteria.

ORs and 95% CIs were calculated by logistic regression analysis adjusted by age, sex, tobacco, alcohol, drugs use (nonsteroidal anti-inflammatory drugs and low-dose acetylsalicylic acid), and histological lesion.

Q values were obtained after applying the False Discovery Rate method for multiple comparisons. Q-values < 0.05 are highlighted in bold.