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. 2021 Feb 4;7(3):e664. doi: 10.1097/TXD.0000000000001098

Table 1.

Comparison of allosure and prospera cell-free DNA assays33,46,51,52

Allosure Prospera
Number of SNPs 266 13 962
Limit of detection 0.16% (Grskovic et al) 0.15% (related donors) 0.23% (unrelated donors) (Altug et al)
Limit of quantification 0.2% (Grskovic et al) 0.15% (related donors) 0.23% (unrelated donors) (Altug et al)
Sensitivity 0.45 (Melancon) 0.59 (Bloom et al) 0.55 (Melancon) 0.887 (Sigdel et al)
Specificity 0.85 (Melancon) 0.85 (Bloom et al) 0.69 (Melancon) 0.726 (Sigdel et al)
Coefficent of variation 7.7% (dd-cfDNA < 2%) 4.5% (dd-cfDNA ≥ 2%) (Grskovic et al) 4.29% (Altug et al)

dd-cfDNA, donor-derived cell-free DNA.