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. 2020 May 26;35(2):573–584. doi: 10.1038/s41375-020-0855-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Panel a shows the mean CD38 expression on immune cell populations and panel b shows the mean total immune cell populations after 2 months of therapy for D-Rd treatment (left) and Rd treatment (right). The visualization method used is the SPADE‐blend tree with which the differential testing results (here, contrasting pre‐ versus on‐treatment sample data) are projected as colored highlighting on the SPADE tree to maximize exploration of the statistical analysis results, simultaneously, in the samples under investigation. Br bright, B_reg regulatory B cell, D-Rd daratumumab plus lenalidomide and dexamethasone, mDC myeloid dendritic cell, Monos monocytes, NK natural killer, NKT natural killer T cell, PBMC peripheral blood mononuclear cell, pDC plasmacytoid dendritic cell, Rd lenalidomide and dexamethasone, T_em effector memory T cell, T_EMRA effector memory CD45RA⁺ T cell, T_reg regulatory T cell. Nodes are colored by decrease (cyan; green, if significant [raw P value]) or increase (magenta; red, if significant [raw P value]).