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. 2020 Oct 9;23(2):408–414. doi: 10.1038/s41436-020-00980-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — (a) Growth parameters of individuals with pathogenic LMNB1/2 variants plotted as Z-scores (standard deviations from the age and sex-matched mean). Black bars, mean Z-score. Dashed lines, 95% confidence interval for general population. (b) Neuroimaging demonstrates reduced cortical size with simplified gyri. Ventricular dilatation reflects accompanying global reduction in white matter. Comparison with age-matched control. Scale bar 2 cm. Axial images, T2-weighted. Coronal, T2 (P8), fluid-attenuated inversion recovery (FLAIR) (control). (c) Photographs of individuals P4, P5, P6, and P8. Written consent obtained from families for photography. OFC occipital frontal circumference.