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. 2021 Jan 6;8(2):e946. doi: 10.1212/NXI.0000000000000946

Figure 2. Laquinimod Acts on Astrocytes to Ameliorate Late Stage EAE.

Figure 2

(A) EAE was induced in control and GFAP-AHR (GFAPCre AHRfl/fl). Animals were treated with daily oral doses of laquinimod or vehicle starting from day 2 after immunization. Clinical scores are mean ± SEM and representative of 2 independent experiments. *p < 0.05. **p < 0.01. ***p < 0.001 by 2-way analysis of variance (ANOVA). (B) Absolute numbers of CNS-infiltrating proinflammatory monocytes as determined by fluorescence-activated cell sorting (FACS) staining for CD11b, CD45, and Ly6C. Data are mean ± SEM. (C) Absolute numbers and (D) relative fractions of CNS-infiltrating T cells were determined by FACS staining for CD3, CD4, IFN-γ, and IL-17A. Data are mean ± SEM of n = 5 mice per group and representative of 3 independent experiments. AHR = aryl hydrocarbon receptor; EAE = experimental autoimmune encephalomyelitis; GFAP = glial fibrillary acidic protein; IFN = interferon; IL = interleukin; n.s. = not significant as determined by 1-way ANOVA followed by the Tukey post hoc test.