Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 14;57(1):10–16. doi: 10.1007/s11626-020-00535-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Figure 3. — Effects of SB203580 and U0126 on the DEX-induced upregulation of CD163 expression. IPKM were treated with (A–D) or without (E–H) 80 ng/ml DEX for 1 d in the presence or absence of 10 μM SB203580 (C, G) or 10 μM U0126 (D, H). DMSO (0.1%) was used as a vehicle control (B, F) because SB203580 and U0126 were dissolved in DMSO. Then, the cells were fixed and immunostained with a specific antibody against CD163 (brown). All nuclei were counterstained with hematoxylin (blue). DEX enhanced the expression of CD163 compared with that seen in the untreated cells (A, E), even in the presence of DMSO (B, F). SB203580 and U0126 had no effect on the basal CD163 expression level (C, D). However, SB203580 blocked the DEX-induced enhancement of CD163 expression (G), while U0126 did not exert any such inhibitory effect (H).