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. 2020 Sep 8;28(2):671–684. doi: 10.1038/s41418-020-00616-8

Fig. 7. UBE2O overexpression predicts poor prognosis and correlates with Mxi1 downregulation in lung cancer patients.

Fig. 7

a Representative IHC staining image for UBE2O in lung adenocarcinoma and paired adjacent lung tissue. Scale bar, 50 μm. b Quantification of UBE2O protein levels in a lung cancer tissue microarray. c Overall survival analysis between UBE2O high and low-expression lung cancer patients by Kaplan–Meier method. d Representative IHC staining images for UBE2O and Mxi1 in two lung adenocarcinoma cases. Scale bar, 50 μm. e The association between UBE2O and Mxi1 protein level in 82 lung adenocarcinoma tissues. f A proposed model how UBE2O regulates Mxi1 in lung cancer. Left panel: UBE2O targets Mxi1 for ubiquitination and degradation at K46 site, therefore leading to tumor progression and radioresistance. Right panel: pharmacological inhibition of UBE2O with ATO blocks the degradation of Mxi1, ultimately resulting in tumor suppression and radiosensitization.