Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 4;11:3097. doi: 10.1038/s41598-021-82728-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Simple mediation model evaluating the effect of body mass index as a mediator of the association between MC4R p.Ile269Asn and type 2 diabetes (% of mediation = 22.7%, Sobel test: z = 4.584; p = 4.55 × 10^–6). Path a, effect of MC4R p.Ile269Asn on body mass index (data is expressed as beta value ± standard error analyzed by a linear regression model adjusted for age and sex); Path b, effect of body mass index on type 2 diabetes (data is expressed as Log Odds Ratio ± standard error analyzed by a logistic regression model controlled for MC4R p.Ile269Asn, and adjusted for age and sex); Path c, total effect of MC4R p.Ile269Asn on type 2 diabetes (data is expressed as Log Odds Ratio ± standard error analyzed by a logistic regression model adjusted for age and sex); Path c′, effect of MC4R p.Ile269Asn on type 2 diabetes (data is expressed as Log Odds Ratio ± standard error analyzed by a logistic regression model controlled for body mass index, and adjusted for age and sex); IE, indirect effect of MC4R p.Ile269Asn on type 2 diabetes (data is expressed as the product of path a and path b); % of mediation is computed as IE divided by path c.