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. 2021 Feb 1;12(2):138. doi: 10.1038/s41419-021-03413-4

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© The Author(s) 2021, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A SNHG1 is overexpressed in TCGA PCa data. B, C Survival analysis of SNHG1 (TCGA PRAD) showed that both overall and disease-free survival were worse in the highly expressed group. D FISH analysis of PCa tissues confirmed that SNHG1 was highly expressed in PCa tissues and located in the nucleus (G means Gleason grade group). E SNHG1 expression was analyzed by qRT-PCR in five PCa cancer cell lines (DU145, PC-3, 22RV1, LNCaP, and C4-2), compared with the human Prostatic immortalized epithelial cells (RWPE-1). F Distribution of SNHG1 in PCa cells detected by fractionation of DU145 and C4-2 cells followed by qRT-PCR. G FISH analysis of DU145 cell. The nuclei were stained with DAPI and 18 S was used as a positive control for cytoplasmic staining. GS means Gleason Score. Scale bar, 20 μm. All data are shown as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001 by two-tailed Student’s t test.