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. 2021 Feb 1;12(2):138. doi: 10.1038/s41419-021-03413-4

Fig. 6. HnRNPL knocdown reverses the carcinogenic effects of SNHG1 promotion on cell metastasis.

Fig. 6

A, B HnRNPL knockdown reversed the SNHG1 overexpression-induced cell migration ability in PCa cells. C western blot showed that forced expression of hnRNPL reversed the SNHG1 upregulating-induced inhibition of E-cadherin protein. D Survival analysis revealed that PCa patients with both low SNHG1 and hnRNPL expression levels had better overall survival and disease-free survival (GEPIA, http://gepia.cancer-pku.cn/). E Schematic diagram displaying the mechanism underlying SNHG1 could competitively bind to hnRNPL leading to downregulating of E-cadherin. **P < 0.01, ***P < 0.001.