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. 2020 Sep 14;28(2):715–729. doi: 10.1038/s41418-020-00618-6

Fig. 6. miR-142-5p-activated HDLECs induce IDO to exhaust CD8+ T cells.

Fig. 6

HDLECs pre-treated with indicated exosomes were cocultured with in vitro-activated CD8+ T cells at a ratio of 1:1 with or without 100 nM of an IDO inhibitor (BMS-986205). The expression of CD69 (a), IFN-γ (b), PD-1 (c), and annexin V (d) in CD8+ T cells was determined by FACS. S/miR-NC exo, Siha/miR-NC exosomes. S/miR-142 exo, Siha/miR-142-5p exosomes. C/miR-NC exo, Caski/miR-NC exosomes. C/miR-142 exo, Caski/miR-142-5p exosomes. Error bars represent the mean ± SD of three independent experiments. ***P < 0.001.