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. 2020 Sep 14;28(2):715–729. doi: 10.1038/s41418-020-00618-6

Fig. 7. Serum exosomal miR-142-5p level correlates with systemic IDO activity and clinicopathological progression in patients with CSCC.

Fig. 7

a Morphology of exosomes isolated and purified from the serum of CSCC patients and healthy controls. Scale Bar: 50 nm. b–c miR-142-5p level and K:T ratio were detected in the serum exosomes of early-stage (FIGO 2018, stages I and II, n = 27) and advanced-stage (FIGO 2018, stages III and IV, n = 17) CSCC patients as well as healthy controls (n = 8). d Correlation analysis of exosomal miR-142-5p and K:T ratio in the serum of CSCC patients and healthy controls. e Proposed schematic diagram of exosomal miR-142-5p promoting lymphatic IDO expression to facilitate the immune escape of cancer cells via CD8+ T cell exhaustion. LECs, lymphatic endothelial cells. miR-142, miR-142-5p. Kyn, kynurenine. Trp, tryptophan. Error bars represent the mean ± SD of three independent experiments. **P < 0.01; ***P < 0.001.