Table 2.
Univariable and multivariable Cox proportional hazard model of metastasis-free survival (MFS) and recurrence-free survival (RFS) in five pTN groups.
| MFS (n = 4236, event = 141) | RFS (n = 4236, event = 410) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariable model | Multivariable model | Univariable model | Multivariable model | ||||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | ||
| Group | pT1N0 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | ||||
| pTxN1 | 6.15 (2.22–17.04) | 0.001 | 6.53 (2.3–18.56) | < .001 | 15.71 (10.45–23.6) | < .001 | 6.67 (4.06–10.94) | < .001 | |
| pT2N0 | 5.34 (3.38–8.45) | < .001 | 5.14 (3.22–8.21) | < .001 | 4.51 (3.42–5.94) | < .001 | 2.18 (1.61–2.96) | < .001 | |
| pT3N0 | 8.44 (5.73–12.44) | < .001 | 6.53 (4.37–9.76) | < .001 | 6.92 (5.50–8.70) | < .001 | 3.66 (2.81–4.76) | < .001 | |
| pT4N0 | 11.75 (3.66–37.75) | < .001 | 7.08 (2.18–22.99) | 0.001 | 17.76 (10.09–31.25) | < .001 | 5.26 (2.79–9.88) | < .001 | |
| Age at operation | 1.02 (1.01–1.04) | 0.003 | 1.01 (1.00–1.02) | 0.005 | |||||
| Body mass index (kg/cm2) | 0.97 (0.92–1.02) | 0.255 | 0.94 (0.91–0.97) | < .001 | 0.96 (0.93–0.99) | 0.022 | |||
| Diabetes | Yes | 1.06 (0.66–1.72) | 0.806 | 1.13 (0.86–1.49) | 0.380 | ||||
| Hypertension | Yes | 1.65 (1.18–2.31) | 0.004 | 1.50 (1.06–2.12) | 0.021 | 1.10 (0.90–1.34) | 0.380 | ||
| ASA | 1 + 2 | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| 3 + 4 | 1.20 (0.53–2.73) | 0.667 | 2.52 (1.71–3.70) | < .001 | 2.21 (1.49–3.29) | < .001 | |||
| Hb | Female (≤ 12), male (≤ 13) | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| Female (> 12), male (> 13) | 0.49 (0.34–0.70) | < .001 | 0.39 (0.32–0.48) | < .001 | 0.76 (0.60–0.96) | 0.020 | |||
| Platelet | ≥ 150, ≤ 450 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | ||||
| < 150 | 0.90 (0.42–1.93) | 0.780 | 0.96 (0.45–2.06) | 0.909 | 0.43 (0.22–0.83) | 0.012 | 0.38 (0.19–0.77) | 0.007 | |
| > 450 | 5.25 (2.44–11.3) | < .001 | 2.18 (1.00–4.75) | 0.051 | 5.17 (3.21–8.33) | < .001 | 1.77 (1.07–2.92) | 0.027 | |
| Creatinine | ≤ 1.3 | 1 (ref) | 1 (ref) | ||||||
| > 1.3 | 1.49 (0.87–2.54) | 0.150 | 1.43 (1.03–1.98) | 0.034 | |||||
| Albumin | ≤ 3.0 | 1 (ref) | 1 (ref) | ||||||
| > 3.0 | 0.61 (0.19–1.90) | 0.391 | 0.47 (0.26–0.85) | 0.013 | |||||
| Nephrectomy | Open surgery | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| Laparoscopic | 0.55 (0.38–0.79) | 0.001 | 0.35 (0.28–0.44) | < .001 | 0.60 (0.46–0.77) | < .001 | |||
| Operative extent | Partial | 1 (ref) | 1 (ref) | 1 (ref) | |||||
| Radical | 3.30 (1.91–5.70) | < .001 | 3.72 (2.72–5.09) | < .001 | 1.83 (1.28–2.61) | 0.001 | |||
| Histology | Clear cell | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | ||||
| Non-clear cell | 0.64 (0.35–1.15) | 0.134 | 0.45 (0.25–0.82) | 0.009 | 0.69 (0.50–0.97) | 0.030 | 0.52 (0.37–0.74) | < .001 | |
| Mixed | 1.74 (0.43–7.03) | 0.440 | 1.77 (0.43–7.28) | 0.426 | 1.70 (0.76–3.81) | 0.198 | 1.07 (0.46–2.51) | 0.875 | |
| Nuclear grade | Grade 1–2 | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | ||||
| Grade 3–4 | 4.06 (2.72–6.06) | < .001 | 2.62 (1.73–3.98) | < .001 | 2.98 (2.35–3.78) | < .001 | 1.95 (1.50–2.53) | < .001 | |
| Sarcomatoid differentiation | Yes | 6.37 (3.34–12.16) | < .001 | 4.60 (2.96–7.14) | < .001 | 1.72 (1.04–2.86) | 0.036 | ||
| Necrosis | Yes | 3.85 (2.57–5.77) | < .001 | 2.72 (2.08–3.54) | < .001 | 1.44 (1.02–2.02) | 0.039 | ||
| Lymphovascular invasion | Yes | 3.51 (2.11–5.83) | < .001 | 3.67 (2.70–4.99) | < .001 | ||||
| Capsular invasion | Yes | 1.74 (1.20–2.51) | 0.004 | 1.40 (1.12–1.77) | 0.004 | ||||