Table 4.
Cox proportional hazard model of MFS, RFS, OS, and CSS in four pTN groups (A) among overall 4236 patients and (B) among only 1382 radical nephrectomized cases.
| Group | MFS (n = 4236, event = 141) | RFS (n = 4236, event = 410) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Event (%) | Univariable model | Multivariable model | N | Event (%) | Univariable model | Multivariable model | |||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |||||
| (A) | ||||||||||||
| pT3-4N0 | 482 | 57 (11.8) | 1 (ref) | 1 (ref) | 482 | 144 (29.9) | 1 (ref) | 1 (ref) | ||||
| pT1-2N0 | 3702 | 80 (2.2) | 0.17 (0.12–0.24) | < .001 | 0.32 (0.23–0.47) | < .001 | 3702 | 239 (6.5) | 0.18 (0.15–0.22) | < .001 | 0.34 (0.27–0.43) | < .001 |
| pT1-2N1 | 25 | 3 (12.0) | 1.06 (0.33–3.39) | 0.922 | 1.34 (0.41–4.33) | 0.629 | 25 | 10 (40.0) | 1.38 (0.73–2.63) | 0.322 | 1.09 (0.51–2.35) | 0.820 |
| pT3-4N1 | 27 | 1 (3.7) | 0.38 (0.05–2.72) | 0.332 | 0.42 (0.06–3.09) | 0.394 | 27 | 17 (63.0) | 3.21 (1.94–5.30) | < .001 | 2.75 (1.53–4.96) | 0.001 |
| Group | OS (n = 4236, event = 351) | CSS (n = 4236, event = 212) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Event (%) | Univariable model | Multivariable model | N | Event (%) | Univariable model | Multivariable model | |||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |||||
| pT3-4N0 | 482 | 109 (22.6) | 1 (ref) | 1 (ref) | 482 | 87 (18.1) | 1 (ref) | 1 (ref) | ||||
| pT1-2N0 | 3702 | 221 (6.0) | 0.25 (0.20–0.32) | < .001 | 0.48 (0.37–0.62) | < .001 | 3702 | 109 (2.9) | 0.15 (0.12–0.20) | < .001 | 0.27 (0.20–0.37) | < .001 |
| pT1-2N1 | 25 | 10 (40.0) | 1.81 (0.95–3.46) | 0.074 | 2.11 (1.05–4.26) | 0.036 | 25 | 8 (32.0) | 1.76 (0.85–3.64) | 0.128 | 1.93 (0.83–4.51) | 0.127 |
| pT3-4N1 | 27 | 11 (40.7) | 2.27 (1.22–4.22) | 0.010 | 3.49 (1.73–7.05) | 0.001 | 27 | 8 (29.6) | 2.02 (0.98–4.17) | 0.058 | 2.73 (1.26–5.93) | 0.011 |
| Group | MFS (n = 1382, event = 56) | RFS (n = 1382, event = 173) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Event (%) | Univariable model | Multivariable model | N | Event (%) | Univariable model | Multivariable model | |||||
| HR (95% CI) | p valve | HR (95% CI) | p valve | HR (95% CI) | p valve | HR (95% CI) | p value | |||||
| (B) | ||||||||||||
| pT3-4N0 | 246 | 27 (11.0) | 1 (ref) | 1 (ref) | 246 | 62 (25.2) | 1 (ref) | 1 (ref) | ||||
| pT1-2N0 | 1108 | 26 (2.4) | 0.18 (0.11–0.32) | < .001 | 0.31 (0.18–0.56) | < .001 | 1108 | 97 (8.8) | 0.27 (0.20–0.38) | < .001 | 0.54 (0.36–0.79) | 0.002 |
| pT1-2N1 | 14 | 3 (21.4) | 2.33 (0.75–7.23) | 0.145 | 2.16 (0.69–6.77) | 0.188 | 14 | 6 (42.9) | 1.92 (0.83–4.44) | 0.128 | 1.35 (0.57–3.18) | 0.499 |
| pT3-4N1 | 14 | 0 (0.0) | 0.33 (0.02–5.78) | 0.451 | 0.23 (0.01–4.10) | 0.317 | 14 | 8 (57.1) | 3.31 (1.58–6.91) | 0.002 | 1.54 (0.70–3.36) | 0.280 |
| Group | OS (n = 1382, event = 140) | CSS (n = 1382, event = 84) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Event (%) | Univariable model | Multivariable model | N | Event (%) | Univariable model | Multivariable model | |||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |||||
| pT3-4N0 | 246 | 42 (17.1) | 1 (ref) | 1 (ref) | 246 | 32 (13.0) | 1 (ref) | 1 (ref) | ||||
| pT1-2N0 | 1108 | 88 (7.9) | 0.36 (0.25–0.52) | < .001 | 0.64 (0.43–0.95) | 0.028 | 1108 | 44 (4.0) | 0.24 (0.15–0.38) | < .001 | 0.52 (0.31–0.87) | 0.013 |
| pT1-2N1 | 14 | 5 (35.7) | 1.93 (0.76–4.88) | 0.167 | 4.51 (1.57–12.98) | 0.005 | 14 | 4 (28.6) | 1.99 (0.70–5.64) | 0.196 | 3.00 (0.87–10.30) | 0.081 |
| pT3-4N1 | 14 | 5 (35.7) | 1.95 (0.77–4.94) | 0.160 | 3.21 (1.1–9.41) | 0.034 | 14 | 4 (28.6) | 2.03 (0.72–5.75) | 0.184 | 2.73 (0.92–8.08) | 0.070 |
(Panel A) Adjusted for hypertension, operative extent, histology, nuclear grade, and necrosis in multivariable model of MFS. Adjusted for BMI, ASA, hemoglobin, platelet, nephrectomy, operative extent, histology, nuclear grade, and necrosis in multivariable model of RFS. Adjusted for age, BMI, diabetes, hypertension, ASA, hemoglobin, nephrectomy, operative extent, nuclear grade, and sarcomatoid differentiation in multivariable model of OS. Adjusted for BMI, diabetes, hypertension, ASA, hemoglobin, nephrectomy, histology, and nuclear grade in multivariable model of CSS.
(Panel B) Adjusted for nuclear grade and necrosis in multivariable model of MFS. Adjusted for ASA, platelet, nephrectomy, nuclear grade, sarcomatoid differentiation, and necrosis in multivariable model of RFS. Adjusted for age, BMI, diabetes, ASA, hemoglobin, nuclear grade, and sarcomatoid differentiation in multivariable model of OS. Adjusted for age, BMI, hemoglobin, creatinine, nuclear grade, sarcomatoid differentiation, and necrosis in multivariable model of CSS.