Table 2.
Risk of Alzheimer’s disease according to BMI changes.
| Men | Women | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Event | Duration | Unadjusted HR (95% CI) |
aAdjusted HR (95% CI) |
Event | Duration | Unadjusted HR (95% CI) |
aAdjusted HR (95% CI) |
|||
| N | Person-years | CIR | N | Person-years | CIR | |||||
| 2-year BMI changes | ||||||||||
| Decrease of > 15.0% | 11 | 670 | 16.4 | 1.04 (0.58–1.89) | 1.00 (0.55–1.82) | 38 | 1034 | 36.8 | 1.64 (1.19–2.26) | 1.51 (1.09–2.09) |
| Decrease of 10.1–15.0% | 39 | 1865 | 20.9 | 1.34 (0.97–1.84) | 1.21 (0.88–1.66) | 91 | 2614 | 34.8 | 1.54 (1.25–1.91) | 1.44 (1.17–1.79) |
| Decrease of 5.1–10.0% | 220 | 11,682 | 18.8 | 1.20 (1.04–1.39) | 1.14 (0.98–1.31) | 335 | 12,653 | 26.5 | 1.17 (1.04–1.32) | 1.14 (1.02–1.29) |
| Stable (± 5.0%) | 1203 | 76,364 | 15.8 | 1.00 | 1.00 | 1,543 | 68,107 | 22.7 | 1.00 | 1.00 |
| Increase of 5.1–10.0% | 162 | 9869 | 16.4 | 1.05 (0.89–1.23) | 0.95 (0.80–1.12) | 240 | 10,728 | 22.4 | 0.99 (0.86–1.13) | 0.94 (0.82–1.08) |
| Increase of 10.1–15.0% | 35 | 1955 | 17.9 | 1.14 (0.82–1.60) | 1.00 (0.71–1.40) | 77 | 2485 | 31.0 | 1.37 (1.09–1.72) | 1.17 (0.93–1.47) |
| Increase of > 15.0% | 18 | 1034 | 17.4 | 1.11 (0.70–1.76) | 0.88 (0.55–1.41) | 43 | 1285 | 33.5 | 1.49 (1.10–2.02) | 1.17 (0.86–1.59) |
| 4-year BMI changes | ||||||||||
| Decrease of > 15.0% | 19 | 1020 | 18.6 | 1.21 (0.77–1.90) | 1.14 (0.73–1.80) | 56 | 1360 | 41.2 | 1.92 (1.47–2.51) | 1.68 (1.29–2.20) |
| Decrease of 10.1–15.0% | 60 | 2782 | 21.6 | 1.39 (1.08–1.81) | 1.33 (1.02–1.72) | 126 | 3409 | 37.0 | 1.72 (1.43–2.06) | 1.60 (1.33–1.92) |
| Decrease of 5.1–10.0% | 245 | 13,426 | 18.2 | 1.18 (1.02–1.35) | 1.13 (0.98–1.30) | 405 | 13,592 | 29.8 | 1.38 (1.23–1.54) | 1.31 (1.17–1.46) |
| Stable (± 5.0%) | 1,071 | 68,805 | 15.6 | 1.00 | 1.00 | 1,354 | 62,410 | 21.7 | 1.00 | 1.00 |
| Increase of 5.1–10.0% | 200 | 12,803 | 15.6 | 1.00 (0.86–1.17) | 0.96 (0.83–1.12) | 284 | 12,723 | 22.3 | 1.03 (0.91–1.17) | 0.98 (0.87–1.12) |
| Increase of 10.1–15.0% | 69 | 3205 | 21.5 | 1.39 (1.09–1.77) | 1.21 (0.94–1.55) | 91 | 3716 | 24.5 | 1.13 (0.91–1.40) | 1.00 (0.80–1.23) |
| Increase of > 15.0% | 24 | 1398 | 17.2 | 1.11 (0.74–1.66) | 0.88 (0.58–1.32) | 51 | 1697 | 30.1 | 1.40 (1.06–1.85) | 1.13 (0.85–1.50) |
BMI body mass index, CIR cumulative incidence rate, HR hazard ratio, CI confidence interval.
aAdjusted for age, insurance premium, initial BMI, smoking status, alcohol consumption, regular exercise, hypertension, diabetes mellitus, and dyslipidemia.