. 2021 Feb 4;11:3087. doi: 10.1038/s41598-021-82593-7

Table 3.

Risk of Alzheimer’s disease according to BMI variability.

	Men					Women
	Event	Duration		Unadjusted HR (95% CI)	^aAdjusted HR (95% CI)	Event	Duration		Unadjusted HR (95% CI)	^aAdjusted HR (95% CI)
	N	Person-years	CIR	Unadjusted HR (95% CI)	^aAdjusted HR (95% CI)	N	Person-years	CIR	Unadjusted HR (95% CI)	^aAdjusted HR (95% CI)
BMI variability
ASV	–	–	–	1.05 (1.03–1.08)	1.05 (1.02–1.08)	–	–	–	1.07 (1.05–1.09)	1.06 (1.03–1.08)
BMI variability
ASV 1st quartile	404	26,149	15.4	1.00	1.00	520	24,913	20.9	1.00	1.00
ASV 2nd quartile	383	25,998	14.7	0.95 (0.83–1.10)	0.93 (0.81–1.07)	532	25,027	21.3	1.02 (0.90–1.15)	1.01 (0.89–1.13)
ASV 3rd quartile	412	25,846	15.9	1.03 (0.90–1.19)	0.98 (0.86–1.13)	595	24,626	24.2	1.16 (1.03–1.30)	1.10 (0.98–1.24)
ASV 4th quartile	489	25,446	19.2	1.25 (1.09–1.42)	1.13 (0.99–1.29)	720	24,341	29.6	1.42 (1.27–1.59)	1.31 (1.17–1.46)

BMI body mass index, ASV average successive variability, CIR cumulative incidence rate, HR hazard ratio, CI confidence interval.

^aAdjusted for age, insurance premium, initial BMI, smoking status, alcohol consumption, regular exercise, hypertension, diabetes mellitus, and dyslipidemia.