TABLE 1.

Background demographic distribution and frequency of the genotype in the pilot study.

	Males (n = 147)			Females (n = 178)
	AD	Controls	p-Value	AD	Controls	p-Value
	(n = 73)	(n = 74)		(n = 84)	(n = 94)
Age (years)	69.4 ± 9.0	67.1 ± 5.3	0.06	65.4 ± 5.9	67.0 ± 6.3	0.08
Education (years)	8.4 ± 4.1	9.3 ± 4.7	0.31	7.4 ± 4.5	5.6 ± 4.7	0.01
Hypertension (%)	55.40%	52.51%	0.69	45.2%	44.7%	0.94
Diabetes mellitus (%)	20.30%	21.10%	0.9	36.9%	20.2%	0.01
Alcohol use (%)	17.60%	16.90%	0.92	1.2%	1.1%	0.94
APOE ε4 carrier	n = 73 30.1%	n = 57 12.3%	0.02	n = 84 43.4%	n = 83 21.7%	0.01
ADH1B
rs1229984 TT/TC/CC	49.4/39.5/11.1	56.2/41.1/2.7	0.14	60.7/35.7/3.6	53.2/42.6/4.3	0.6
ADH1C
rs2241894 CC/CT/TT	43.8/42.5/13.7	52.1/38.4/9.6	0.55	54.8/44.0/1.2	46.8/43.6/9.6	0.05
ALDH1B1
rs2073478 GG/GT/TT	47.9/36.6/15.5	52.8/31.9/15.3	0.82	41.0/51.8/7.2	48.4/36.6/15.1	0.07
ALDH2
rs886205 GG/GA/AA	77.0/21.6/1.4	78.1/20.5/1.4	0.99	82.1/17.9/0.0	74.5/22.3/3.2	0.18
rs4767944 TT/TC/CC	48.6/41.9/9.5	41.1/49.3/9.6	0.63	51.8/41.0/7.2	47.8/38.0/14.1	0.34
rs4648328 CC/CT/TT	67.1/28.8/4.1	57.5/38.4/4.1	0.46	68.7/26.5/4.8	64.9/31.9/3.2	0.66
rs671 GG/GA/AA	46.6/35.6/17.8	46.6/42.5/11.0	0.44	47.6/41.7/10.7	41.5/50.0/8.5	0.53

N, number, AD, Alzheimer disease, ADH, alcohol dehydrogenase, ALDH, aldehyde dehydrogenase. Data are expressed as percentage or mean ± SE. Comparisons between AD cases and controls were analyzed using the χ2 test or t-test where appropriate.