TABLE 4.

Associations of the candidate SNPs with AD in the extension study.

Gene	SNP	Position	Dominant p-values	Additive p-values	Recessive p-values, (OR, 95% CI)
ADH1B: Missense Variantc.143A > G, p.His48Arg	rs1229984	chr4:99318162	M: 0.46, F: 0.78	M: 0.41, F: 1.00	M: 0.58, F: 0.59
ADH1C: Synonymous Variant, c.453T > A,C p.Thr151 =	rs2241894	chr4:99344976	M: 0.24, F: 0.39	M: 0.09, F: 0.29	M: 0.08, F: 0.72
ALDH1B1: Missense Variant, c.320G > A, p.Arg107His	rs2073478	chr9:38396068	M: 0.12, F: 0.12	M: 0.34, F: 0.40	M: 0.72, F: 0.77
ALDH2: 2KB Upstream Variant, A > G	rs886205	chr12:111766623	M: 0.48 F: 0.51	M: 0.19, F: 0.46	M: NA, F: 0.60
ALDH2: Missense Variant, c.1510G > A, p.Glu504Lys	rs671	chr12:111803962	M: 0.57, F: 0.65	M: 0.39, F: 0.56	M: 0.29, F: 0.59

M, male, F, female, NA, not applicable, OR, odds ratio, 95% CI = 95% confidence interval, Logistic regression was performed, adjusting for age, education, HTN, DM, and alcohol use. p-value with Bonferroni correction for significance was 0.01.