Table 2.
Partitioned SNP-heritability (h2SNP) of Human Tobacco Consumption with Model Organism Nicotine Genes.
| Model components (buffer size) | Subset 1 (n1 = 41,263) | Subset 2 (n2 = 41,368) | Subset 3 (n3 = 41,213) | All (n = 123,844) | ||||
|---|---|---|---|---|---|---|---|---|
| # SNPs | h2SNP (S.E.) | Enrichment | h2SNP (S.E.) | Enrichment | h2SNP (S.E.) | Enrichment | % total h2SNP | |
| Model 1 (0 kB) | ||||||||
| Protein coding regions | 81453 | 0.38% (0.16%) | 2.90c | 0.33% (0.16%) | 2.38c | 0.55% (0.18%) | 3.32c | 4.96% |
| Surrounding regions | NA | NA | NA | NA | NA | NA | NA | NA |
| All other variants | 4575485 | 7.14% (0.78%) | 0.97c | 7.59% (0.78%) | 0.98 | 8.85% (0.80%) | 0.96b | 94.92% |
| Total heritability | 4656938 | 7.53% (0.79%) | NA | 7.92% (0.78%) | NA | 9.40% (0.81%) | NA | NA |
| Model 2 (5 kB) | ||||||||
| Protein coding regions | 81453 | 0.22% (0.17%) | 1.62c | 0.15% (0.16%) | 1.11 | 0.42% (0.19%) | 2.54c | 3.26% |
| Surrounding regions | 10815 | 0.45% (0.18%) | 25.20c | 0.58% (0.19%) | 31.45c | 0.34% (0.19%) | 15.68c | 4.95% |
| All other variants | 4564670 | 6.92% (0.79%) | 0.93c | 7.24% (0.78%) | 0.93c | 8.67% (0.81%) | 0.94c | 91.44% |
| Total heritability | 4656938 | 7.53% (0.79%) | NA | 7.97% (0.78%) | NA | 9.42% (0.81%) | NA | NA |
| Model 3 (10 kB) | ||||||||
| Protein coding regions | 81453 | 0.19% (0.17%) | 1.27 | 0.09% (0.16%) | 0.63c | 0.29% (0.18%) | 1.77c | 2.16% |
| Surrounding regions | 21288 | 0.82% (0.21%) | 21.56c | 0.90% (0.21%) | 24.43c | 0.77% (0.21%) | 17.82c | 9.84% |
| All other variants | 4554197 | 6.61% (0.78%) | 0.90c | 7.04% (0.77%) | 0.90c | 8.41% (0.80%) | 0.91c | 88.00% |
| Total heritability | 4656938 | 7.57% (0.78%) | NA | 8.03% (0.78%) | NA | 9.47% (0.81%) | NA | NA |
| Model 4 (25 kB) | ||||||||
| Protein coding regions | 81453 | 0.12% (0.16%) | 0.85 | 0.11% (0.16%) | 0.76 | 0.28% (0.18%) | 1.67c | 1.92% |
| Surrounding regions | 53341 | 1.03% (0.23%) | 11.56c | 0.96% (0.23%) | 10.50c | 1.02% (0.24%) | 9.36c | 12.36% |
| All other variants | 4522144 | 6.36% (0.78%) | 0.88c | 6.93% (0.77%) | 0.89c | 8.18% (0.80%) | 0.89c | 85.71% |
| Total heritability | 4656938 | 7.59% (0.78%) | NA | 8.00% (0.78%) | NA | 9.48% (0.81%) | NA | NA |
| Model 5 (35 kB) | ||||||||
| Protein coding regions | 81453 | 0.13% (0.16%) | 0.97 | 0.13% (0.16%) | 0.94 | 0.30% (0.18%) | 1.81c | 2.16% |
| Surrounding regions | 74436 | 1.04% (0.24%) | 8.39c | 0.95% (0.24%) | 7.48c | 1.05% (0.25%) | 6.94c | 12.50% |
| All other variants | 4501049 | 6.32% (0.77%) | 0.88c | 6.90% (0.77%) | 0.89c | 8.12% (0.80%) | 0.89c | 85.22% |
| Total heritability | 4656938 | 7.59% (0.78%) | NA | 7.98% (0.78%) | NA | 9.45% (0.81%) | NA | NA |
| Model 6 (50 kB) | ||||||||
| Protein coding regions | 81453 | 0.29% (0.16%) | 1.97c | 0.26% (0.16%) | 1.84c | 0.50% (0.18%) | 2.98c | 4.17% |
| Surrounding regions | 841092 | 3.22% (0.53%) | 2.15c | 3.30% (0.53%) | 2.26c | 2.74% (0.53%) | 1.60c | 36.47% |
| All other variants | 3734393 | 4.23% (0.74%) | 0.66c | 4.53% (0.73%) | 0.70c | 6.24% (0.77%) | 0.82c | 59.12% |
| Total heritability | 4656938 | 7.67% (0.79%) | NA | 8.09% (0.78%) | NA | 9.48% (0.81%) | NA | NA |
This table shows the heritability of human tobacco consumption attributed to genes associated with nicotine exposure from various animal paradigms. We report the total heritability, the proportion of heritability within and around model organism genes as well as the degree of enrichment from our partitioned heritability analyses by subset. Note that we performed 6 total models with varying lengths of genomic regions surrounding the model organism genes. NA not applicable, SE standard error. Notations: ap < 0.05, bp < 0.01, cp < 0.001.