Table 1.
Outcomes of acute myeloid leukemia patients with TP73 mutations, patients with TP53 mutations, and patients without TP53 or TP73 mutation (wild-type)
| TP73m | TP53m | Wild-type | Pa | Pa | Pa | |
|---|---|---|---|---|---|---|
| Endpoint | n=11 | n=87 | n=930 | TP73m vs TP53m | TP73m vs wt | TP53m vs wt |
| Complete remission, % | 64 | 40 | 71 | 0.20 | 0.52 | <0.001 |
| Disease-free survival | 0.005 | 0.59 | <0.001 | |||
| Median, years | 2.0 | 0.4 | 1.1 | |||
| % Disease-free at 1 year (95% CI) | 100 | 11 (4–24) | 52 (48–56) | |||
| % Disease-free at 3 years (95% CI) | 29 (4–61) | 9 (2–21) | 33 (30–37) | |||
| Overall survival | <0.001 | 0.28 | <0.001 | |||
| Median, years | 3.9 | 0.4 | 1.5 | |||
| % Alive at 1 year (95% CI) | 100 | 15 (8–23) | 63 (60–66) | |||
| % Alive at 3 years (95% CI) | 55 (23–78) | 5 (1–10) | 36 (33–39) | |||
Abbreviations: CI, confidence interval; m, mutated; n, number; wt, wild-type.
a
P-values for categorical variables are from Fisher’s exact test, P-values for time to event variables are from the log-rank test.