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. 2021 Feb 4;12(2):152. doi: 10.1038/s41419-021-03434-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Flow cytometry examination of apoptotic CAL27 cells with Tan IIA treatment for 72 h; n = 3 independent biological replications, one-way ANOVA; **p < 0.01, ***p < 0.001. B and C CAL27 cells were treated with Tan IIA for 72 h, cell lysate was subjected to cleaved-caspase 3 activity analysis (B) and IB analysis (C). For B, n = 3 independent biological replications, one-way ANOVA; *p < 0.05, ***p < 0.001. D CAL27 cells were treated with Tan IIA for 72 h and subjected to IF analysis with cleaved-caspase 3 antibody. Scale bar, 10 μm; n = 3 independent biological replications, one-way ANOVA; **p < 0.01, ***p < 0.001. E Knockdown of Aurora B decreased the sensitivity to Tan IIA. Soft agar assay analysis of the anti-tumor effect of Tan IIA on shGFP and shAurora B-expressing CAL27 cells (left and middle), the inhibitory ratio of Tan IIA on colony formation was calculated (right); n = 3 independent biological replications, two-way ANOVA, ***p < 0.001; ns, not statistically significant.