Table 2.

Results of the Mendelian Randomization analyses in CoLaus|PsyCoLaus, NESDA|NTR, and in their combined dataset.

Dataset	Exposures	Outcomes	N SNPs	Inverse variance weighted			Simple median			Weighted median
				Beta	SE	p	Beta	SE	p	Beta	SE	p
CoLaus|PsyCoLaus + NESDA|NTR combined	BMI	Atypical MDD vs controls	594	−0.14	0.19	0.471	−0.14	0.29	0.632	−0.06	0.30	0.843
		Non-atypical MDD vs controls	593	0.04	0.12	0.731	−0.03	0.18	0.882	−0.07	0.19	0.725
		Increase in appetite	593	0.68	0.23	0.004*	0.77	0.37	0.036	1.11	0.39	0.004*
		Hypersomnia	593	0.05	0.20	0.812	0.16	0.29	0.584	0.36	0.34	0.298
		Mood reactivity	593	−0.23	0.16	0.132	−0.36	0.24	0.130	−0.04	0.24	0.881
		Leaden paralysis	593	−0.11	0.17	0.518	−0.21	0.27	0.436	−0.46	0.28	0.096
		Rejection sensitivity	593	−0.23	0.16	0.152	−0.30	0.26	0.248	0.14	0.29	0.643
	WHR	Atypical MDD vs controls	330	0.33	0.25	0.199	−0.09	0.40	0.822	−0.06	0.39	0.877
		Non-atypical MDD vs controls	329	−0.11	0.16	0.482	0.09	0.23	0.691	−0.03	0.24	0.900
		Increase in appetite	330	0.78	0.31	0.011	0.87	0.44	0.050	0.91	0.52	0.078
		Hypersomnia	331	0.46	0.27	0.092	0.64	0.39	0.099	0.32	0.43	0.459
		Mood reactivity	331	0.40	0.22	0.068	0.44	0.30	0.152	0.44	0.32	0.172
		Leaden paralysis	331	0.08	0.22	0.724	0.38	0.34	0.261	0.41	0.34	0.223
		Rejection sensitivity	330	−0.13	0.23	0.568	−0.46	0.31	0.140	−0.09	0.35	0.787
CoLaus|PsyCoLaus	BMI	Atypical MDD vs controls	593	0.24	0.24	0.319	0.30	0.36	0.396	0.26	0.40	0.526
		Non-atypical MDD vs controls	593	−0.13	0.17	0.447	0.13	0.26	0.605	0.19	0.30	0.537
		Increase in appetite	592	0.82	0.28	0.004*	0.55	0.44	0.206	0.75	0.47	0.113
		Hypersomnia	592	0.35	0.25	0.153	0.19	0.38	0.621	0.47	0.42	0.267
		Mood reactivity	592	0.16	0.21	0.442	0.01	0.33	0.980	0.74	0.35	0.036
		Leaden paralysis	592	0.26	0.24	0.286	−0.02	0.37	0.957	−0.18	0.36	0.607
		Rejection sensitivity	591	0.08	0.20	0.677	−0.05	0.31	0.879	0.02	0.34	0.943
	WHR	Atypical MDD vs controls	330	0.05	0.32	0.879	0.13	0.47	0.781	0.20	0.49	0.678
		Non-atypical MDD vs controls	330	−0.20	0.22	0.352	−0.04	0.35	0.911	−0.14	0.34	0.688
		Increase in appetite	330	0.56	0.40	0.154	0.35	0.56	0.529	0.36	0.58	0.541
		Hypersomnia	330	0.23	0.33	0.487	0.70	0.50	0.164	−0.15	0.50	0.766
		Mood reactivity	330	0.05	0.30	0.861	−0.01	0.43	0.974	−0.11	0.46	0.809
		Leaden paralysis	330	−0.03	0.31	0.935	−0.25	0.45	0.585	−0.43	0.47	0.368
		Rejection sensitivity	330	−0.30	0.27	0.268	−0.62	0.39	0.109	−0.54	0.42	0.194
NESDA|NTR	BMI	Atypical MDD vs controls	592	−0.80	0.32	0.013	−1.03	0.48	0.031	−0.15	0.52	0.771
		Non-atypical MDD vs controls	592	0.19	0.16	0.236	0.23	0.23	0.315	0.38	0.26	0.140
		Increase in appetite	592	0.36	0.42	0.392	0.14	0.62	0.825	0.14	0.73	0.846
		Hypersomnia	592	−0.49	0.32	0.131	−0.45	0.50	0.376	−0.18	0.56	0.742
		Mood reactivity	591	−0.66	0.22	0.003*	−0.54	0.33	0.103	−0.50	0.37	0.169
		Leaden paralysis	592	−0.57	0.26	0.027	−0.25	0.40	0.541	−0.51	0.44	0.249
		Rejection sensitivity	592	−0.91	0.28	0.001*	−0.97	0.43	0.022	−1.11	0.49	0.023
	WHR	Atypical MDD vs controls	330	0.81	0.43	0.061	0.22	0.65	0.732	0.84	0.65	0.197
		Non-atypical MDD vs controls	330	0.01	0.22	0.977	0.10	0.31	0.742	−0.09	0.34	0.801
		Increase in appetite	330	1.37	0.53	0.009*	1.07	0.79	0.172	1.53	0.83	0.066
		Hypersomnia	330	0.82	0.43	0.055	1.45	0.63	0.021	1.47	0.68	0.029
		Mood reactivity	330	0.77	0.32	0.017	0.76	0.45	0.094	0.79	0.48	0.100
		Leaden paralysis	330	0.23	0.35	0.508	−0.15	0.53	0.771	0.01	0.56	0.988
		Rejection sensitivity	329	0.06	0.37	0.877	−0.13	0.56	0.817	0.09	0.60	0.878

Nominal significant associations are in bold and associations on symptoms surviving correction for multiple testing alpha level of 0.01 (0.05/5) are denoted with an asterisk.

BMI body mass index, WHR waist-to-hip ratio.