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. 2021 Feb 4;12(2):155. doi: 10.1038/s41419-021-03426-z

Fig. 1. MIF supports tumor growth in a CRC mouse model.

Fig. 1

A Schematic of the AOM/DSS CRC mouse model. Visualization of tumor burden started at week 5 by colonoscopy. At 12 weeks post-AOM injection, established tumors were analyzed. B Representative colonoscopy images of the colonic lumen of the indicated genotypes at week 5 post-AOM. Dashed lines indicate the tumor borders. C Average number of tumors (left) and tumor sizes (right) in Mif+/+ and Mif−/− mice at 5 weeks post-AOM injection. Numbers were determined by colonoscopy in living mice. S1 = small tumors to S3 = larger tumors. D Representative H&E-stained colonic tissues with tumors from Mif+/+ and Mif−/− mice at week 12 post-AOM injection. Scale bars, 600 µm. E Average number of tumors per mouse (left) and tumor sizes (right) of the indicated mice at 12 weeks post-AOM injection. C, E n, mouse numbers. Black lines, mean. Student’s t test of indicated groups.