Table 1.
Proteasome subunits names and function.
| Subcomplex | Saccharomyces cerevisiae | Homo sapiens | Function |
|---|---|---|---|
| 19 S lid | Rpn3 | PSMD3 | Structural |
| Rpn5 | PSMD12 | Structural | |
| Rpn6 | PSMD11 | Structural | |
| Rpn7 | PSMD6 | Structural | |
| Rpn8 | PSMD7 | Structural | |
| Rpn9 | PSMD13 | Structural | |
| Rpn11 | PSMD14 | Deubiquitinase, Ub removal | |
| Rpn12 | PSMD8 | Structural | |
| Rpn15 | PSMD9 | Structural | |
| 19 S base | Rpn1 | PSMD2 | Ubp6 and Ub/Ubl binding |
| Rpn2 | PSMD1 | Structural | |
| Rpn10 | PSMD4 | Initial Ub/Ubl binding | |
| Rpn13 | ADRM1 | ||
| Rpt1 | PSMC2 | ATPase subunits, substrates binding, unfolding, and translocation | |
| Rpt2 | PSMC1 | ||
| Rpt3 | PSMC4 | ||
| Rpt4 | PSMC6 | ||
| Rpt5 | PSMC3 | ||
| Rpt6 | PSMC5 | ||
| 20 S α-subunits | α1 | PSMA6 | 20 S gate opening |
| α2 | PSMA2 | ||
| α3 | PSMA4 | ||
| α4 | PSMA7 | ||
| α5 | PSMA5 | ||
| α6 | PSMA1 | ||
| α7 | PSMA3 | ||
| 20 S β-subunits | β1 | PSMB6 | Caspase-like activity |
| β1i | PSMB9 | Chymotrypsin-like activity | |
| β2 | PSMB7 | Trypsin-like activity | |
| β2i | PSMB10 | Trypsin-like activity | |
| β3 | PSMB3 | ||
| β4 | PSMB2 | ||
| β5 | PSMB5 | Chymotrypsin-like activity | |
| β5i | PSMB8 | Chymotrypsin-like activity | |
| β6 | PSMB1 | ||
| β7 | PSMB4 | ||
| Associated DUBs | Ubp6 | USP14 | Deubiquitinase, 19 S activation |
| — | UCH37 |