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. 2021 Jan 28;18(1):113–125. doi: 10.1007/s13770-020-00322-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Inhibiting inflammatory cytokines expression in cartilage. A Representative immunofluorescence images of TNF-α and IL-1β expression in cartilage 2 weeks post-injection. B Representative immunofluorescence images of TNF-α and IL-1β expression in cartilage 12 weeks post-injection. C Quantitative statistics of TNF-α expression in cartilage 2 weeks and 12 weeks post-injection. D Quantitative statistics of IL-1β expression in cartilage 2 weeks and 12 weeks post-injection (*p < 0.05, **p < 0.01, ***p < 0.001 compared with the Untreated group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 compared with the HA group)