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. 2020 Oct 6;73(1):111–121. doi: 10.1007/s43440-020-00164-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a–f Phenobarbital (PB), lamotrigine (LTG), oxcarbazepine (OXC), pregabalin (PGB), topiramate (TPM), and their combination (at the fixed-ratio of 1:1:1) in the tonic–clonic seizure (MES) model in mice. Logarithms of doses of PB, LTG, TPM, PGB, OXC, and the three-drug combinations were plotted on X-axis, while the anticonvulsant effects of the tested AEDs were plotted on Y-axis. Dose–response relationship effects were linearly related for the investigated AEDs and their combinations. The horizontally placed 5th probit illustrates median effective doses (ED₅₀) of AEDs when intersecting with dose–response lines for particular drugs