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. 2021 Jan 22;11:607473. doi: 10.3389/fimmu.2020.607473

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Copyright © 2021 Giese, Schilloks, Degroote, Weigand, Renner, Wolf, Hauck and Deeg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proliferative capacity of porcine lymphocytes. Mitogens were used for stimulation of lymphocytes analyzed after 48 h of culture: (A) pokeweed mitogen (PWM) (B) concanavalin A (ConA) or (C) phytohaemagglutinin (PHA). Proliferation rate of stimulated lymphocytes did not differ between wild-type (wt, n=12) and INS^C94Y tg pigs (n=10) stimulated by ConA and PWM (ns = not significant). After PHA-stimulation, lymphocytes of INS^C94Y tg pigs (n=11) revealed a significantly 5-fold decreased proliferation rate (***p < 0.001) compared to non-transgenic wild-type littermates (n=13). Data are represented as means +SEM.