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. 2021 Jan 22;13:574041. doi: 10.3389/fnmol.2020.574041

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Copyright © 2021 Liu, Li, Huang, Lin, Ji, Huang, Liu, Wu, Wu, Jiang, Ye and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The area of spared white matter after injury. Demyelination was mainly located on the ipsilateral side at the injury epicenter [A, red: myelin basic protein (MBP), labeled myelin sheathes; green: SMI312, labeled axons; blue: DAPI, labeled nucleus]. High magnifications of demyelination are shown in (B–D,G). The area of spared white matter was significantly decreased in the two injured groups, and the area of spared white matter in the rapamycin-treated group was significantly greater than that in the vehicle-treated group (E,F). Longitudinal sections are shown in (H). WPI, weeks post-injury; R, rostral; C, caudal; D, dorsal; V, ventral. ^∗∗P < 0.01, ^∗∗∗P < 0.001, ^*⁣*⁣**P < 0.0001. Scale bar = 200 μm (A–H) and 20 μm (B–D). Error bars are mean ± SEM.