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. 2021 Feb 4;11:3086. doi: 10.1038/s41598-021-82587-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ALFF higher in pediatric HIV vs. Control. In pediatric HIV patients (n = 11) compared to controls (n = 16), we observed significantly higher cluster FWE-corrected p < 0.05 and uncorrected p < 0.05 values for the ALFF resting state fMRI activity in bilateral cerebral white matter. The regional activity was overlaid on anatomical mean of all 27 subjects’ T₁ images. (A) Right cerebral white matter/right medial prefrontal cortex, (B) left cerebral white matter/left prefrontal cortex, (C) left cerebral white matter, (D) left cerebral white matter.