Table 3.

Correlation of resting fMRI data with viral load.

Type of resting fMRI data	Brain Regions	Peak p (uncorr) and Type of correlation with log10 viral load	Number of cluster voxels	MNI coordinate (mm) x	MNI coordinate (mm) y	MNI coordinate (mm) x	Peak t	Figure
ALFF	Right cerebral white matter	0.001 (+ve)	6	12	34	− 2	4.24	Figure 1A
	Left cerebral white matter	0.002 (+ve)	3	− 36	34	16	3.97	Figure 1B
	Left cerebral white matter	0.004 (+ve)	8	− 44	44	− 2	3.35	Figure 1B
	Right cerebral white matter	0.004 (+ve)	3	16	40	− 6	3.32	Figure 1A
	Right cerebral white matter	0.006 (+ve)	3	16	36	− 14	3.12	Figure 1A
ReHo	Right cerebral white matter	0.002 (+ve)	4	16	32	− 16	3.82	Figure 2A

Brain regions masked with significantly higher regional neuronal activity in the pediatric HIV patients compared to healthy controls, showed positive correlation (peak uncorrected p  <  0.01, cluster size ≥ 3) of log₁₀ viral load with regional neuronal activity in the 11 pediatric HIV patients. + ve indicate positive correlation and − ve indicate negative correlation.