Table 3.
Associations of the normalized initial glycans.
| GPs | Dementia vs. NC | Dementia vs. MCI | MCI vs. NC | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI)# | p-adjusted | q* | OR (95% CI)# | p-adjusted | q* | OR (95% CI)# | p-adjusted | q* | |
| GP1 | 6.78 (3.01–15.29) | 3.91E−06 | 1.72E−05 | 0.80 (0.54–1.18) | 2.59E−01 | 3.97E−01 | 9.53 (4.24–21.41) | 4.73E−08 | 1.04E−06 |
| GP2 | 1.64 (1.07–2.52) | 2.42E−02 | 3.80E−02 | 0.91 (0.62–1.34) | 6.19E−01 | 6.81E−01 | 1.96 (1.25–3.08) | 3.36E−03 | 8.21E−03 |
| GP4 | 0.84 (0.58–1.22) | 3.63E−01 | 4.70E−01 | 0.81 (0.55–1.21) | 3.01E−01 | 4.13E−01 | 1.12 (0.78–1.60) | 5.48E−01 | 5.74E−01 |
| GP5 | 32.78 (8.31–129.27) | 6.19E−07 | 4.50E−06 | 1.34 (0.85–2.11) | 2.03E−01 | 3.67E−01 | 8.16 (2.95–22.58) | 5.29E−05 | 2.91E−04 |
| GP6 | 1.16 (0.78–1.71) | 4.65E−01 | 5.11E−01 | 0.73 (0.49–1.09) | 1.27E−01 | 2.53E−01 | 1.29 (0.94–1.77) | 1.12E−01 | 1.36E−01 |
| GP7 | 4.71 (2.29–9.67) | 2.46E−05 | 6.77E−05 | 1.17 (0.79–1.73) | 4.25E−01 | 5.43E−01 | 6.58 (3.02–14.34) | 2.14E−06 | 2.35E−05 |
| GP8 | 6.02 (3.05–11.89) | 2.31E−07 | 3.10E−06 | 3.46 (2.02–5.94) | 6.58E−06 | 1.45E−04 | 1.03 (0.74–1.43) | 8.79E−01 | 8.79E−01 |
| GP9 | 2.06 (1.37–3.10) | 4.94E−04 | 1.09E−03 | 1.65 (1.12–2.44) | 1.14E−02 | 3.57E−02 | 1.37 (0.98–1.93) | 6.87E−02 | 8.89E−02 |
| GP10 | 4.87 (2.66–8.90) | 2.82E−07 | 3.10E−06 | 1.45 (1.00–2.10) | 4.94E−02 | 1.21E−01 | 2.51 (1.54–4.11) | 2.40E−04 | 1.06E−03 |
| GP11 | 1.34 (0.62–2.90) | 4.56E−01 | 5.11E−01 | 0.44 (0.25–0.77) | 3.77E−03 | 1.38E−02 | 4.37 (1.95–9.79) | 3.34E−04 | 1.22E−03 |
| GP12 | 2.24 (1.39–3.63) | 9.86E−04 | 1.97E−03 | 1.78 (1.09–2.88) | 2.02E−02 | 5.55E−02 | 1.41 (0.89–2.24) | 1.48E−01 | 1.71E−01 |
| GP13 | 6.65 (2.55–17.36) | 1.09E−04 | 2.66E−04 | 1.16 (0.80–1.68) | 4.45E−01 | 5.43E−01 | 4.89 (2.32–10.30) | 3.02E−05 | 2.21E−04 |
| GP14 | 0.49 (0.30–0.78) | 2.78E−03 | 5.10E−03 | 1.02 (0.69–1.50) | 9.26E−01 | 9.26E−01 | 0.62 (0.43–0.88) | 7.08E−03 | 1.56E−02 |
| GP15 | 8.10 (3.53–18.61) | 8.18E−07 | 4.50E−06 | 1.11 (0.78–1.57) | 5.80E−01 | 6.72E−01 | 3.28 (1.65–6.53) | 7.09E−04 | 2.23E−03 |
| GP16 | 0.34 (0.21–0.55) | 1.09E−05 | 4.00E−05 | 0.38 (0.23–0.63) | 1.74E−04 | 1.28E−03 | 0.70 (0.50–0.99) | 4.11E−02 | 6.45E−02 |
| GP17 | 0.96 (0.63–1.45) | 8.30E−01 | 8.33E−01 | 1.32 (0.85–2.05) | 2.17E−01 | 3.67E−01 | 0.63 (0.42–0.93) | 2.12E−02 | 3.58E−02 |
| GP18 | 0.36 (0.22–0.57) | 2.38E−05 | 6.77E−05 | 0.38 (0.22–0.66) | 5.89E−04 | 3.24E−03 | 0.65 (0.46–0.92) | 1.38E−02 | 2.52E−02 |
| GP19 | 0.68 (0.39–1.20) | 1.83E−01 | 2.52E−01 | 0.58 (0.30–1.15) | 1.19E−01 | 2.53E−01 | 0.85 (0.62–1.17) | 3.21E−01 | 3.53E−01 |
| GP21 | 1.60 (0.98–2.62) | 6.18E−02 | 9.06E−02 | 4.49 (2.15–9.38) | 6.49E−05 | 7.14E−04 | 0.58 (0.33–1.00) | 4.99E−02 | 7.32E−02 |
| GP22 | 3.59 (1.40–9.19) | 7.76E−03 | 1.31E−02 | 1.04 (0.69–1.56) | 8.53E−01 | 8.93E−01 | 4.60 (1.85–11.43) | 1.00E−03 | 2.75E−03 |
| GP23 | 0.87 (0.64–1.20) | 4.07E−01 | 4.98E−01 | 2.19 (1.31–3.64) | 2.62E−03 | 1.15E−02 | 0.57 (0.37–0.87) | 9.40E−03 | 1.88E−02 |
| GP24 | 1.04 (0.73–1.48) | 8.33E−01 | 8.33E−01 | 1.21 (0.86–1.70) | 2.71E−01 | 3.97E−01 | 0.69 (0.47–1.02) | 6.37E−02 | 8.75E−02 |
*q < 0.05: significant after correction for FDR (false discovery rate).
NC normal cognitive functioning, MCI mild cognitive impairment.
#Adjusting for the effects of age, sex, BMI, levels of education, history of malignant tumor, habit of salt intake, ischemic stroke, diabetes, hypertension and dyslipidemia (adjusting for the above effects other than age and sex for dementia vs. NC).
p < 0.05 was considered statistically significant.