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. 2021 Feb 4;11:3199. doi: 10.1038/s41598-021-82905-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differential gene expression analyses. (a) differentially expressed genes were determined among the three biological conditions (baseline VS experimental group: log-phase VS T = 0, log-phase VS T = 4, and T = 0 VS T = 4). The numbers of significantly up-regulated genes are shown on the top of the arrows while the numbers of significantly down-regulated genes are shown on the bottom. (b) Volcano plots (red: down-regulated genes; and blue: up-regulated genes). (c) Venn diagrams illustrating the numbers of differentially expressed genes common and unique among different strains of M. tuberculosis.