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. 2020 Dec 17;28(2):538–556. doi: 10.1038/s41418-020-00697-5

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Fig. 2 — Stimulus-induced phosphorylation is frequently used to regulate DUB-substrate recruitment during developmental cell-fate decisions. This can occur through interaction-promoting or -inhibiting substrate modification (upper panel). Examples in which substrate phosphorylation promotes and inhibits DUB-substrate interaction include USP15-β-catenin and USP21-NANOG, respectively. Stimulus-induced phosphorylation can also occur on DUBs to promote interactions with substrates (e.g., USP9X-ankyrin G, lower panel).