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. 2021 Feb 4;11:3021. doi: 10.1038/s41598-021-81920-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Spatial organization of actin filaments in MSCs adhering to the Nichoid artificial niche. (a,b) 3D reconstruction from confocal acquisitions of cells grown into the Nichoid (a) and on the Control (b). In green are identified actin fibers and in blue the cell nuclei. The SZ2080 photopolymer, used to fabricate the niche, is fluorescent at all excitation wavelengths, including at 405 nm that is the excitation wavelength of the fluorescent dye used to label the nuclear DNA. (c,d) Orthogonal (yellow ROIs) and sagittal (red ROIs) projections of MSCs grown into the Nichoid (c) and on a flat control substrate (d). (e) Actin expression level calculated by western blot. Statistics: Mann–Whitney test. *Corresponds to p < 0.05.