Table 1.
Four disrupted components and aberrant functional connectivity in FED or RD identified using network-based statistical analysis.
| Significant connections | Functional connectivity | ||||||
|---|---|---|---|---|---|---|---|
| Network | Seed region | Coordinates (x, y, z) | Target region | Coordinates (x, y, z) | FED | RD | HC |
| FED vs. HC (Component 1) | |||||||
| SMN-DAN | R—Insula | (36, −18, 9) | R – Parieto-occipital cortex | (46, −70, 20) | 0 | −0.17 | −0.15 |
| SMN-DMN (4) | L—S2 | (−50, −15, 17) | R—Inferior parietal lobule | (49, −70, 30) | −0.18 | −0.36 | −0.32 |
| L—Insula | (−34, −21, 10) | R—Inferior parietal lobule | (49, −70, 30) | −0.06 | −0.21 | −0.19 | |
| R—Insula | (36, −18, 9) | R—Inferior parietal lobule | (49, −70, 30) | −0.06 | −0.23 | −0.23 | |
| R—Auditory cortex | (55, −12, 6) | R—Inferior parietal lobule | (49, −70, 30) | −0.26 | −0.44 | −0.44 | |
| RD vs. HC (Component 2) | |||||||
| SMN-SN (4) | L—S2 | (−50, −15, 17) | L—Inferior parietal lobule | (−61, −40, 36) | 0.21 | 0.28 | 0.12 |
| L—Auditory cortex | (−51, −19, 7) | L—Inferior parietal lobule | (−61, −40, 36) | 0.31 | 0.41 | 0.26 | |
| R—S2 | (48, −10, 16) | L—Inferior parietal lobule | (−61, −40, 36) | 0.21 | 0.23 | 0.09 | |
| R—Auditory cortex | (55, −12, 6) | L—Inferior parietal lobule | (−61, −40, 36) | 0.38 | 0.4 | 0.25 | |
| SMN-ECN (3) | L—Somato-motor network component A | (−23, −23, 63) | L—Inferior parietal lobule | (−48, −52, 52) | −0.18 | −0.01 | −0.17 |
| L—S2 | (−50, −15, 17) | L—Inferior parietal lobule | (−48, −52, 52) | −0.12 | −0.04 | −0.18 | |
| R—Auditory cortex | (55, −12, 6) | L—Inferior parietal lobule | (−48, −52, 52) | −0.07 | 0.02 | −0.11 | |
| DAN-ECN | L—Post-central cortex | (−36, −38, 55) | L—Inferior parietal lobule | (−48, −52, 52) | 0.15 | 0.25 | 0.12 |
| SMN- DMN | L—Somato-motor network component A | (−23, −23, 63) | L—Inferior parietal lobule | (−53, −54, 30) | −0.3 | −0.16 | −0.32 |
| RD vs. HC (Component 3) | |||||||
| SN – SN (5) | L—Inferior parietal lobule | (−61, −40, 36) | R—Lateral prefrontal cortex | (32, 49, 25) | 0.29 | 0.2 | 0.39 |
| L—Inferior parietal lobule | (−61, −40, 36) | R—Ventrolateral prefrontal cortex | (45, 46, 0) | 0.29 | 0.15 | 0.39 | |
| R—Inferior parietal lobule | (52, −49 49) | R—Ventrolateral prefrontal cortex | (45, 46, 0) | 0.34 | 0.14 | 0.43 | |
| L—Inferior parietal lobule | (−61, −40, 36) | R—Posterior-medial prefrontal cortex | (6, 28, 33) | 0.16 | 0.02 | 0.19 | |
| R—Posterior-medial prefrontal cortex | (6, 28, 33) | R—anterior Cingulate cortex | (5, 19, 23) | 0.68 | 0.53 | 0.69 | |
| SN – ECN (4) | R—Dorsal prefrontal cortex | (13, 15, 65) | L—Inferior parietal lobule | (−48, −52, 52) | −0.06 | −0.19 | −0.01 |
| R—Ventrolateral prefrontal cortex | (45, 46, 0) | L—Inferior parietal lobule | (−48, −52, 52) | 0.36 | 0.25 | 0.42 | |
| L—Inferior parietal lobule | (−61, −40, 36) | L—Posterior-medial prefrontal cortex | (−5, 32, 44) | −0.06 | −0.17 | 0 | |
| R—Ventrolateral prefrontal cortex | (45, 46, 0) | R—Inferior parietal lobule | (52, −49, 49) | 0.28 | 0.17 | 0.37 | |
| ECN – ECN (5) | L—Inferior parietal lobule | (−48, −52, 52) | L—Posterior-medial prefrontal cortex | (−5, 32, 44) | 0.45 | 0.4 | 0.6 |
| L—Intraparietal sulcus | (−39, −50, 47) | R—Dorsolateral prefrontal cortex | (32, 29, 46) | 0.12 | −0.03 | 0.12 | |
| L—Inferior parietal lobule | (−48, −52, 52) | R—Dorsolateral prefrontal cortex | (32, 29, 46) | 0.26 | 0.14 | 0.37 | |
| R—Inferior parietal lobule | (52, −49 49) | R—Dorsolateral prefrontal cortex | (32, 29, 46) | 0.63 | 0.48 | 0.72 | |
| L—Inferior parietal lobule | (−48, −52, 52) | R—Posterior-medial prefrontal cortex | (4, 39, 42) | 0.08 | −0.03 | 0.15 | |
| ECN – DMN (2) | R—Posterior-medial prefrontal cortex | (4, 39, 42) | L—Inferior parietal lobule | (−53, −54, 30) | 0.44 | 0.26 | 0.44 |
| L—Inferior parietal lobule | (−48, −52, 52) | R—Dorsal prefrontal cortex | (9, 50, 39) | −0.18 | −0.34 | −0.18 | |
| FED vs. RD | |||||||
| (Component 4) | |||||||
| SMN-DAN | R—Insula | (36, −18, 9) | R—Parieto-occipital cortex | (46, −70, 20) | 0 | −0.17 | −0.15 |
| SMN-DMN (9) | L—S2 | (−50, −15, 17) | L—Parahippocampal cortex | (−27, −31, −18) | 0.04 | −0.17 | −0.08 |
| L—Somato-motor network component A | (−23, −23, 63) | R—Inferior parietal lobule | (49, −70, 30) | −0.2 | −0.39 | −0.32 | |
| L—S2 | (−50, −15, 17) | R—Inferior parietal lobule | (49, −70, 30) | −0.18 | −0.36 | −0.32 | |
| L—Auditory cortex | (−51, −19, 7) | R—Inferior parietal lobule | (49, −70, 30) | −0.23 | −0.42 | −0.36 | |
| R—Insula | (36, −18, 9) | R—Inferior parietal lobule | (49, −70, 30) | −0.06 | −0.23 | −0.23 | |
| R—Auditory cortex | (55, −12, 6) | R—Inferior parietal lobule | (49, −70, 30) | −0.26 | −0.44 | −0.44 | |
| L—S2 | (−50, −15, 17) | R—Parahippocampal cortex | (27, −28, −19) | 0.01 | −0.17 | −0.02 | |
| L—Insula | (−34, −21, 10) | R—Parahippocampal cortex | (27, −28, −19) | 0.07 | −0.09 | 0.07 | |
| L—Auditory cortex | (−51, −19, 7) | R—Parahippocampal cortex | (27, −28, −19) | 0.03 | −0.14 | −0.04 | |