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. 2021 Feb 4;11:3015. doi: 10.1038/s41598-021-82566-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) The distribution of pruritus scores is shown, according to the etiology of chronic liver disease. HBsAg-negative status (P = 0.004) as factors significantly associated with pruritus in multivariate analysis. Severity of pruritus scores was not significantly different between diseases. (b) The distribution of pruritus scores is shown, according to the presence of hepatocellular carcinoma (HCC). There was no significant difference in the incidence or degree of pruritus regarding the presence or absence of HCC.