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. 2021 Feb 4;11:3142. doi: 10.1038/s41598-021-82801-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Network enrichment of differentially abundant oocyte proteins. Differentially abundant proteins were analyzed for connectivity and functional enrichment using high confidence protein interactions (confidence > 0.9; line thickness indicates strength of support for protein interactions). Proteins with increased abundance in oocytes from mated (top) and unmated (bottom) females had significantly more interactions than expected. Proteins with greater abundance in oocytes from mated females were significantly enriched for ribosome biogenesis (red) and transmembrane proteins (purple) whereas proteins with greater abundance in oocytes from unmated females were significantly enriched for associations with the nucleus (yellow).