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. 2021 Feb 4;11:3123. doi: 10.1038/s41598-021-82364-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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tDCS immediate effects over SEPs in S1 cortex. (A) Schematic representation of tDCS protocol. (B) SEP average (n = 30) from a representative animal during control (black trace), anodal (red trace) and cathodal (blue trace) tDCS applied at 50, 100, 150 and 200 μA. (C) Quantification and statistical results of anodal tDCS (red histograms) and cathodal tDCS (blue histograms) effects on SEP amplitude. Mean (bars) and individual amplitude data (circles) are represented as percentage of change with respect to control values for all animals (n = 14 mice). Two-way repeated-measures ANOVA, CURRENT INTENSITY effect, F_3,39 = 3.316, p = 0.030, POLARITY effect, F_1,13 = 51.081, p < 0.001, CURRENT INTENSITY × POLARITY interaction, F_3,39 = 27.818, p < 0.001, Holm-Sidak post hoc test. **p < 0.01; ***p < 0.001.