Figure 1.

Maximum likelihood phylogenetic analysis of 135 Treponema pallidum subspecies pallidum and 2 Treponema pallidum subspecies pertenue genomes. The boxes in the columns show (from the left) for each strain: its lineage, its country of origin, sexual orientation of the patient, and its macrolide resistance genetic profile. For macrolide resistance, if either the A2058G or A2059G mutation in the 23S rRNA genes was present, the strain was classified as resistant. If mixed alleles were detected in these sites, the strain was classified as ‘‘uncertain’’. The scale represents the number of substitutions per site.